Research Fellowship

Peritoneal Tumorigenesis and Inflammation are Ameliorated by Humidified-Warm Carbon Dioxide Insufflation in the Mouse

S Carpinteri, S Sampurno, MP Bernardi, M Germann, J Malaterre, A Heriot, BA Chambers, SE Mutsaers, AC Lynch, RG Ramsay

2015-12-01

Background: Conventional laparoscopic surgery uses CO<inf>2</inf> that is dry and cold, which can damage peritoneal surfaces. It i..

Defective Myb function ablates Cyclin E1 expression and perturbs intestinal carcinogenesis

D Cheasley, L Pereira, S Sampurno, O Sieber, R Jorissen, H Xu, M Germann, Y Yuqian, RG Ramsay, J Malaterre

2015-08-01

Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (MybPlt4) were exa..

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5 stem cells

DJ Flanagan, TJ Phesse, N Barker, RHM Schwab, N Amin, J Malaterre, DE Stange, CJ Nowell, SA Currie, JTS Saw, E Beuchert, RG Ramsay, OJ Sansom, M Ernst, H Clevers, E Vincan

2015-05-12

The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cel..

MYB elongation is regulated by the nucleic acid binding of NFekB p50 to the intronic stem-loop region

LA Pereira, HJ Hugo, J Malaterre, X Huiling, S Sonza, A Cures, DFJ Purcell, PA Ramsland, S Gerondakis, TJ Gonda, RG Ramsay

2015-04-08

MYB transcriptional elongation is regulated by an attenuator sequence within intron 1 that has been proposed to encode a RNA stem ..

Myb via TGFβ is required for collagen type 1 production and skin integrity

S Sampurno, R Cross, H Pearson, P Kaur, J Malaterre, RG Ramsay

2015-04-01

Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the archi..

Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein

RS Cross, J Malaterre, AJ Davenport, S Carpinteri, RL Anderson, PK Darcy, RG Ramsay

2015-01-01

Cancers can be addicted to continued and relatively high expression of nuclear oncoproteins. This is evident in colorectal cancer ..

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

H Xu, Y Yan, S Deb, D Rangasamy, M Germann, J Malaterre, NC Eder, RL Ward, NJ Hawkins, RW Tothill, L Chen, NJ Mortensen, SB Fox, MJ McKay, RG Ramsay

2014-12-11

Loss of heterozygosity (LOH) of the adenomatous polyposis coli (. APC) gene triggers a series of molecular events leading to intes..

Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis

M Germann, H Xu, J Malaterre, S Sampurno, M Huyghe, D Cheasley, S Fre, RG Ramsay

2014-11-01

Deletion studies confirm Wnt, Notch and Myb transcriptional pathway engagement in intestinal tumorigenesis. Nevertheless, their co..

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration

TJ Phesse, M Buchert, E Stuart, DJ Flanagan, M Faux, S Afshar-Sterle, F Walker, HH Zhang, CJ Nowell, R Jorissen, CW Tan, Y Hirokawa, MF Eissmann, AR Poh, J Malaterre, HB Pearson, DG Kirsch, P Provero, V Poli, RG Ramsay

2014-09-30

Most colon cancers arise from somatic mutations in the tumor suppressor gene APC (adenomatous polyposis coli), and these mutations..

Marker genes identify three somatic cell types in the fetal mouse ovary

RH Rastetter, P Bernard, JS Palmer, AA Chassot, H Chen, PS Western, RG Ramsay, MC Chaboissier, D Wilhelm

2014-09-05

The two main functions of the ovary are the production of oocytes, which allows the continuation of the species, and secretion of ..

Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation

P Daniel, G Filiz, DV Brown, F Hollande, M Gonzales, G D'Abaco, N Papalexis, WA Phillips, J Malaterre, RG Ramsay, T Mantamadiotis

2014-06-30

The cyclic-AMP response element binding (CREB) protein has been shown to have a pivotal role in cell survival and cell proliferati..

RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas

S Deb, H Xu, J Tuynman, J George, Y Yan, J Li, RL Ward, N Mortensen, NJ Hawkins, MJ McKay, RG Ramsay, SB Fox

2014-03-18

Background: RAD21 is a component of the cohesion complex and is integral to chromosome segregation and error-free DNA repair. RAD2..

Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice

LM Hare, TJ Phesse, PM Waring, KG Montgomery, KM Kinross, K Mills, V Roh, JK Heath, RG Ramsay, M Ernst, WA Phillips

2014-03-01

PIK3CA, the gene encoding the p110α catalytic subunit of PI3K (phosphoinositide 3-kinase), is mutated in approximately 20% of spor..

Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells

HJ Hugo, L Pereira, R Suryadinata, Y Drabsch, TJ Gonda, NPAD Gunasinghe, C Pinto, ETL Soo, BJW van Denderen, P Hill, RG Ramsay, B Sarcevic, DF Newgreen, EW Thompson

2013-11-27

Introduction: Epithelial-to-mesenchymal transition (EMT) promotes cell migration and is important in metastasis. Cellular prolifer..

The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis

S Sampurno, A Bijenhof, D Cheasley, H Xu, S Robine, D Hilton, WS Alexander, L Pereira, T Mantamadiotis, J Malaterre, RG Ramsay

2013-04-01

The gastrointestinal (GI) epithelium is constantly renewing, depending upon the intestinal stem cells (ISC) regulated by a spectru..

The CSF-1 receptor fashions the intestinal stem cell niche

D Akcora, D Huynh, S Lightowler, M Germann, S Robine, JR de May, JW Pollard, ER Stanley, J Malaterre, RG Ramsay

2013-03-01

Gastrointestinal (GI) homeostasis requires the action of multiple pathways. There is some controversy regarding whether small inte..

CSF-1 Receptor-Dependent Colon Development, Homeostasis and Inflammatory Stress Response

D Huynh, D Akçora, J Malaterre, CK Chan, XM Dai, I Bertoncello, ER Stanley, RG Ramsay

2013-02-22

The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) directly regulates the development of Paneth cells (PC) and influences p..

Delayed development of specific thyroid hormone-regulated events in transthyretin null mice

JA Monk, NA Sims, KM Dziegielewska, RE Weiss, RG Ramsay, SJ Richardson

2013-01-01

Thyroid hormones (THs) are vital for normal postnatal development. Extracellular TH distributor proteins create an intravascular r..

Inflammation and APC Mutation: the Perfect Storm for the Initiation of Colon Cancer

Robert G Ramsay

2013-01-01

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules

AJ Faure, D Schmidt, S Watt, PC Schwalie, MD Wilson, H Xu, RG Ramsay, DT Odom, P Flicek

2012-11-01

The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master reg..

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis

J Bellis, I Duluc, B Romagnolo, C Perret, MC Faux, D Dujardin, C Formstone, S Lightowler, RG Ramsay, JN Freund, JR De Mey

2012-08-01

The stem cells (SCs) at the bottom of intestinal crypts tightly contact niche-supporting cells and fuel the extraordinary tissue r..

Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

P Mitra, LA Pereira, Y Drabsch, RG Ramsay, TJ Gonda

2012-07-01

The MYB proto-oncogene is expressed in most estrogen receptor-positive (ERα⁺) breast tumors and cell lines. Expression ..

RAD21 mutations cause a human cohesinopathy

MA Deardorff, JJ Wilde, M Albrecht, E Dickinson, S Tennstedt, D Braunholz, M Mönnich, Y Yan, W Xu, MC Gil-Rodríguez, D Clark, H Hakonarson, S Halbach, LD Michelis, A Rampuria, E Rossier, S Spranger, L Van Maldergem, SA Lynch, G Gillessen-Kaesbach

2012-06-08

The evolutionarily conserved cohesin complex was originally described for its role in regulating sister-chromatid cohesion during ..

Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation

J Malaterre, CS McPherson, D Denoyer, E Lai, J Hagekyriakou, S Lightowler, K Shudo, M Ernst, DM Ashley, JL Short, G Wheeler, RG Ramsay

2012-01-01

Radiation-induced brain injury occurs in many patients receiving cranial radiation therapy, and these deleterious effects are most..

Optimizing DNA Vaccines Against Nuclear Oncogenes

Sandra Carpinteri

2012-01-01

Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses

MA Alikhan, CV Jones, TM Williams, AG Beckhouse, AL Fletcher, MM Kett, S Sakkal, CS Samuel, RG Ramsay, JA Deane, CA Wells, MH Little, DA Hume, SD Ricardo

2011-09-01

Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized a..

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis

A Sakthianandeswaren, M Christie, C D'Andreti, C Tsui, RN Jorissen, S Li, NI Fleming, P Gibbs, L Lipton, J Malaterre, RG Ramsay, TJ Phesse, M Ernst, RE Jeffery, R Poulsom, SJ Leedham, S Segditsas, IPM Tomlinson, OK Bernhard, RJ Simpson

2011-05-15

Studies employing mouse models have identified crypt base and position +4 cells as strong candidates for intestinal epithelial ste..